The SSRIs are reported to cause sexual dysfunction in the following descending order of frequency: citalopram 72.7%; paroxetine 70.7%; sertraline 62.9%; fluvoxamine 62.3%; fluoxetine 57.7%.Weight gain Weight gain is another troubling side effect. Paroxetine, fluoxetine, citalopram and sertraline have been shown to increase body weight after 612 months of therapy.Low levels of serotonin and norepinephrine have not been proven to cause depression but it is widely believed that elevation of these chemicals is associated with improvement in mood in depressed people.All selective serotonin reuptake inhibitors have the same principal mechanism of action.Celexa is manufactured by Forest Pharmaceuticals, Inc.Lexapro (Escitalopram oxalate) is the newest and most selective of the SSRIs approved by the FDA in August 14, 2002. The brain communicates with itself through the use of special chemicals called neurotransmitters, such as serotonin and norepinephrine.SSRIs seem to relieve symptoms of depression by blocking the reabsorption (reuptake) of serotonin by certain nerve cells in the brain.This leaves more serotonin available, which enhances neurotransmission and improves mood.
Citalopram has been associated with loss of libido and may be associated with a relatively higher level of sexual dysfunction compared with sertraline.
Nausea The most common side effect associated with use of SSRIs is nausea.
Paroxetine and sertraline have been associated with slightly more cases of nausea.
Sexual dysfunction The SSRIs as a class produce a variety of sexual side effects, including anorgasmia, decreased libido, impotence, and delayed ejaculation.
Analysis of the clinical trials suggests that fluvoxamine and fluoxetine are less likely to produce sexual side effects than paroxetine and sertraline.